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De Marco's is in the heart of Little Italy on India Street, just blocks from the Porto Vista Hotel and Suites, DoubleTree by Hilton Hotel San Diego Downtown, The Trolley Stop, Maritime Museum, San Diego County Administration Center and Waterfront Park. Our main room is designed in a cozy, rustic setting, with walls lined with family pictures welcoming you and your guests as if they were in our own home. It is ideal for private parties, wine tastings, corporate meetings, wedding rehearsal dinners, holiday parties, and more!